Monday, February 28, 2011

High Cholesterol Causes Heart Disease? : Part 5

Are you worries about your high cholesterol? Do you avoid butter, cheese and cream because you are afraid of dying of heart attack? Do you take cholesterol lowering drug? If so, you are a victim of the cholesterol campaign, the greatest medical scandal in modern times. Even worse, you may suffer from bad memory, muscle weakness, pain in your legs, sexual impotency or cancer, not because you are getting old, but because of the harmful effects from your cholesterol treatment. 

Don't you believe me? Neither does your doctor because all the 'experts' have said that reduction of cholesterol is harmless. Well, they are wrong, and today, I would like to share with you readers out there, about statins and how cholesterol lowering drug works, and their harmful effects. Not only pharmaceutical companies and their paid researchers succeeded in presenting the cholesterol reducing drugs as a gift from heaven, but the very idea that saturated fat and high cholesterol are bad for health, is created out in the thin air. In spite of that, it has accepted uncritically across the globe.

We have been told, that saturated fat is bad for us as it causes the raise of cholesterol levels in the body. Let's see. Fat, is composed of various types of fatty acids and fatty acids are molecular chains of various lengths, mainly composed of carbon and hydrogen atoms.  Saturated fatty acids are stable molecules because they are saturated with atoms of hydrogen. One of the main constituents of our cell walls is saturated fat. We produced saturated fat ourselves to build new cells and the excess is deposited in our fat cells for later use. 

Do you believe that humans are designed to produce a toxic molecule that will eventually kills us? Could the dominant fat in mother's milk be poisonous to the baby? Absurd isn't it? It is simply a masterpiece of deceit to convince the world that too much of saturated fat in our food should cause a deadly disease. 

It is impossible to build new cell walls and nerve fibres without cholesterol. We produce other important molecules such as sex and stress hormones by changing the structure of the cholesterol molecule a little. With the help of the sun, our skin cells use the same method to produce Vitamin D. Cholesterol is also vital importance to our brain. We cannot think clearly without it. Not only cholesterol is used by the brain cells and all nerve fibres as an important building material, the chemical processes necessary for the creation of nerve impulses are also dependant on its presence. It is therefore no surprise that the brain has the highest concentration of cholesterol in the body. 

The importance of cholesterol is apparent from the fact that the richest source cholesterol from our food is the egg, because much cholesterol is needed to produce a healthy living warm-blooded creature. Make sense? I always ask my colleagues why does an egg contains so much of cholesterol. They couldn't give me the correct answer. If any of you understand what makes a living creature healthy, you will know the importance of cholesterol in the body. 

Cholesterol is so important, that all cells are able to produce it by themselves. In fact, everyday, we produce three to five times more cholesterol then we eat from our diet. If we eat to little in our diet, the production goes up, and if we gorge on animal food, the production goes down. That is why it is so difficult to reduce and control blood cholesterol with diet. The idea that a little extra cholesterol in the blood should result in a deadly disease seemed to be utterly silly yet ridiculous. It's like saying that the burning houses are set on fire by the fire brigade.

Now, let me introduce to you the 'best seller' drug of all drugs, cholesterol lowering drug. It's also known as statins. There are a number of different statins. Lovastatin, simvastatin, cerivastatin, fluvastatin, pravastatin, atorvastatin, etc. Why so many? Actually, cerivastatin was voluntarily withdrawn after killing rather too many people. It was said to have cause muscle disintegration, followed by death. In fact, all statins CAN cause muscle disintegration and death. Statins comes in different brand names in different countries. In UK, we have simvastatin, also known as Zocor. In other countries like Malaysia, we have atorvastatin, which is widely known as Lipitor. This drug is the most widely prescribed of the statins. Lipitor sits proudly at the top of the sales pyramid with over 6 billion pounds per year in sales!

 Now, let me try to explain to you where and how statins work in our body. We have been told by doctors that statins reduce the synthesis of cholesterol in our body. Right? The answer is yes. By reducing cholesterol synthesis, they should in turn reduce the production of VLDL in the liver. True? Well, LDL level is actually controlled by the number of LDL receptors in the body. The more LDL receptors you have, the more LDL will be removed from the circulation.

Unlike VDLD and IDL, LDLs do not shrink, thereby changing into other types of lipoprotein. LDLs wander about in the circulation, essentially unaltered, until they are lock on to an LDL receptor. At this point, the LDL and all its contents are pulled into cells and then broken down, along with the receptors itself. And if you want to remove more LDLs, more receptors must be manufactured, then transported to the surface of the cell.

If any of you heard about a condition by the name of Familial Hypercholesterolimia (FH), the you will know that the LDL levels are extremely high. Reason? The underlying problem in FH is a lack of LDL receptors. With very few receptors available, LDL is stuck in the circulation and consequently its level skyrockets.

Now, I will explain in a nutshell how statins work, to lower cholesterol and LDL level in our body.

  1. They lower cholesterol sysnthesis in the liver.
  2. The liver starts running out of the cholesterol needed to make VLDLs.
  3. The liver then has to increase the number of LDL receptors to pull cholesterol back in to make more VLDLs.
  4. More LDL is dragged back into the liver, as a result, LDL level in the blood falls.

But, if you think that the only action of statins is to reduce the synthesis of cholesterol in the liver, then you are dead wrong! Statins do many other things in our body. Tons of other side effects of statins include muscle weakness, loss of memory, congestive heart failure and even death. When you go against the nature's way, when you push your cholesterol level down, you cancer rates goes up, and the lower your cholesterol level is, the rate of cancer is off the roof, astronomically. Well, isn't it absurd, you take cholesterol lowering drug to prevent heart disease, but it could cause congestive heart failure? Wonderful. 


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