The SOY evidence..journals and studies

It's about time, more people need to know and realize about the danger of soybean. Some people ask me, you can write what you think, and the public who read all the soybean posts I wrote earlier, may be biased or untrue. Now, I hereby present to you, some of the medical and nutrition journals about soybean. For soybean lovers, have an open mind, read the medical journals. There is no debate about it, case closed! 

Meanwhile, the medical and nutrition journals below are just part of the whole complete archives which indicate and prove that soybean is NOT a healthy food and it causes tons of adverse impact to our health including infertility, thyroid issues, malnutrition, endocrine disruption, cancer and even reduced penis size and length and low sperm count. And yes, man boobs and erectile dysfunction too! 

Soybean – Is it a healthy food? Is it safe?

- Neurotoxicology journals

-  Reproductive toxicology journals

-  Nutrition journals

-  American journals of Neuroendocrinology 

 - Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland

- Department of Reproduction and Genetics, Nanjing University of Clinical Medicine, China

- Division of Biochemical Toxicology, NCTR, Jefferson, AR, USA

- Laboratory of Neuroendocrinology, Neuroscience Institute of Torino, University of Torino, Torino, Italy

- Department of Oncology, Georgetown University, Washington, DC 20057, USA

-  Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, NIH, United States

- Center for Autonomic and Peripheral Nerve Disorders, Beth Israel Medical Deaconess Center, Harvard Medical School, Department of Medicine

- Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, USA

- Department of Pediatrics, Division of Pediatric Endocrinology, The Johns Hopkins School of Medicine, USA

- Institute of Brain and Behavioural Sciences, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi, China.

FDA Scientists Against Soy: 

1999, NIH NIEHS scientists Dr. Doerge and Dr. Sheehan have for decades consistently proven highly toxic soy-cause of multiple adverse body & brain effects, especially caused to most developmentally fragile fetus, infants, and children.

www.alkalizeforhealth.net/Lsoy2.htm

1999, Phytoestrogens are compounds found in plant foods (largely soybeans) that exhibit estrogen-like activity, and display both estrogen-like activity and anti-estrogen effects.  Interindividual diversity and complexity in dietary phytoestrogen absorption and metabolism make their bioactivity unpredictable.  Their actions in specific cells are determined by many factors; levels of estrogen receptor-alpha and -beta, and the diverse cocktail of co-activators and co-repressors present in any given cell type.  Overall, it is naïve to assume that exposure to these compounds is always good. Inappropriate or excessive exposure to phytoestrogens may be detrimental to health. 

www.ncbi.nlm.nih.gov/pubmed/10548876

2001, NIEHS Report: Dietary (soy) genistein produced effects in multiple estrogen-sensitive tissues in male and female mice consistent with estrogenic activity…...within exposure ranges in humans.

www.ncbi.nlm.nih.gov/pubmed/11738518

2002, Neurobehavioral effects of dietary soy phytoestrogens; These studies used a commercially available diet rich in phytoestrogens (Phyto-rich) verses a diet relatively free of phytoestrogens (Phyto-free).  The phyto-rich diet fed to adult male and female rats produced anxiolytic effects.  When learning and memory parameters were examined the visual-spatial memory (VSM), the diet treatments significantly changed the typical sexually dimorphic pattern of VSM.  Phyto-rich females executed the VSM task in a manner similar to that of phyto-free fed males.  Phyto-rich males VSM was comparable to Phyto-free fed females.  Results indicate that consumption of dietary phytoestrogens resulting in high plasma isoflavone levels (in many cases over a relative short interval of consumption) can significantly alter sexually dimorphic brain region, anxiety, learning, and memory.  These findings identify biological actions of phytoestrogens on the brain and behavior.   

www.ncbi.nlm.nih.gov/pubmed/11836067

Feminize Male Brain: 

2003 study, Johns Hopkins, AB Wisniewski et al, Perinatal (soy) genistein exposure results in transient and lasting alterations in masculinization of the reproductive system. Exposure to genistein during gestation and lactation de-masculinizes the reproductive system in rats. 

www.ncbi.nlm.nih.gov/pubmed/12629420

2010, Soy As An Endocrine Disruptor: Cause For Caution:  Endocrine disrupting compounds (EDCs_ alter the function of the endocrine system and consequently cause adverse health effects.  Phytoestrogens, natural plant compounds abundantly found in soy and soy products, behave as weak estrogen mimics or as anti-estrogen.  They are considered to be EDCs.  Supporting evidence that consumption of phytoestrogens is beneficial is indirect and inconsistent.  Lifetime exposure to estrogenic substances, especially during critical periods of development, has been associated with formation of malignancies and several anomalies of the reproductive systems.  Phytoestrogen consumption in infants is of particular concern.  Possible adverse effects should not be taken lightly.   

www.ncbi.nlm.nih.gov/upbmed/21175082

Evidence That Early Exposure to Soy Hormone Disruptors Can Masculinize Female Brain, and Feminize Male Brain:

Soy de-masculinized male, and de-feminized females…(Soy) Genistein during critical period could disrupt brain differentiation. 

www.ncbi.nlm.nih.gov/pubmed/17109964

Neonatal (soy) genistein or BPA alters sexual differentiation de-masculinizing males and de-feminizing females… Phytoestrogenic genistein is a endocrine active compounds (EAC). Acute exposure to EAC alter AVPV Development.

www.ncbi.nlm.nih.gov/pubmed/16427766

2011, Developmental exposure to estrogenic compounds can disrupt sexual differentiation in adult reproductive function in many animals including humans. Phytoestrogens in the diet comprise a significant source of estrogenic exposure to humans, particularly infants who are fed soy-based infant formula. Studies clearly demonstrate that environmentally relevant doses of genistein have significant negative impacts on ovarian differentiation, estrous cyclicity, and fertility in the rodent model. Additional studies of reproductive function in human populations exposed to phytoestrogens during development are warranted.

www.ncbi.nlm.nih.gov/pubmed/20955782

Masculinize Female Brain: 

Soy De-feminizes female brain.  Reversal of sex roles in genetic female mice by disruption of estrogen receptor gene. 

www.ncbi.nlm.nih.gov/pubmed/13129486

Deficiency of normal estrogen receptor gene function led to behavioral change in female mice, aggression was increased. Disruption of ER gene led to a pattern of hormonal and neural changes which caused female to lose their normal female-typical behavior and to behave more like males. 

www.ncbi.nlm.nih.gov/pubmed/8990081

2011 study; A Lehraiki et al. It is well known that genistein, an isoflavone found in soybeans and soy products, mimics the actions of estrogens …. Genistein inhibits testosterone secretion by fetal Leydig cells during early fetal development within the “masculinization programming window." These results suggest that fetal exposure to phytoestrogens can affect the development and function of the male reproductive system.

www.ncbi.nlm.nih.gov/pubmed/21624456

2007, Genistein is a phytoestrogen, abundant in soybeans that can bind estrogen receptors and sex hormone binding proteins, exerting both estrogenic and antiestrogenic activity. Results demonstrate that genistein acts similarly to estradiol, has an organizational effect on vasotocin system and copulatory behavior. In this avian (quail) model embryonic exposure to phytoestrogens may have life-long effects on sexual differentiation of brain structures and behaviors. 

www.ncbi.nlm.nih.gov/pubmed/17274996

Infant Leukemia: 

2010, Genistein is a bioflavonoid enriched in soy products. High levels of maternal soy consumption linked to the development of infant leukemia. Genistein induced infant leukemia. 

www.ncbi.nlm.nih.gov/pubmed/20638367

2007, Study demonstrates that biologically relevant concentrations of soy genistein flavonoids can induce abnormalities in mixed-linage leukemia. Particularly alarming knowing mother’s metabolism can lead to higher flavonoid concentration on fetal side. Raise public awareness and set guidelines for marketing flavonoid supplements to reduce risk of infant leukemias. 

www.ncbi.nlm.nih.gov/pubmed/17468513

2010- Endocrine disruptors, chemicals that disturb the actions of endogenous hormone, have been implicated in birth defects associated with hormone-dependent development.Phytoestrogens are a class of endocrine disruptors found in plants. ….soy phytoestrogens.Effects of genistein on reproductive development and spatial learning required exposure throughout the pre-and postnatal periods. 

www.ncbi.nlm.nih.gov/pubmed/20053350

2011, Isoflavone research revealed adverse effects on reproductive system. This is also the case with tumor-promoting effects on breast tissue. Questions about the effectiveness and safety of isoflavones have to be clarified. There are concerns about the maternal consumption of isoflavones due to the development of leukemia in infants. 

 www.ncbi.nlm.nih.gov/pubmed/21438720

Exposure To Soy Hormone Disruptors Prove Adverse Male Reproductive Effects: 

2008, Endocrine disrupting chemicals (EDCs) exert hormone-like activity and exposure to these compounds may induce deleterious effects including functional alterations that contribute to decreased reproduction and fitness.  The EDCs examined included estradiol, androgen active compounds, soy phytoestrogens, and atrazine.  All EDCs impaired reproduction.  Male sexual behavior proved to be a sensitive index of EDC exposure and embryonic exposure to a variety of EDCs consistently resulted in impaired male sexual behavior.     www.ncbi.nlm.nih.gov/pubmed/18006066

2011. A number of reports demonstrate adverse effects of soy isoflavones due to their estrogen-like properties has increased. Loss of libido and erectile dysfunction is associated with soy product consumption. This case emphasized the impact of soy isoflavones in the regulation of sex hormone and associated physical alterations.

www.ncbi.nlm.nih.gov/pubmed/21353476

Soy is reproductive endocrine disruptor: decreases male fertility. 

 www.ncbi.nlm.nih.gov/pubmed/19919579

Soy is associated with lower sperm count; 

www.ncbi.nlm.nih.gov/pubmed/18650557

2010, Soy and soy-based products are widely consumed by infants and adult individuals. These studies show that long-term exposure to dietary soy and phytoestrogens may affect male reproductive function resulting in a decrease in sperm count and fertility.

www.ncbi.nlm.nih.gov/pubmed/20171261

Soy-cause of Erectile Dysfunction in adulthood. 

www.ncbi.nlm.nih.gov/pubmed/17673432

Exposure To Soy Hormone Disruptors Prove Adverse Female Reproductive Effects:

2009, Adverse soy-transfer through generations: Genistein at 500ppm and ethinyl estradiol at 50ppb produced similar effects in continuously exposed rats, including decreased body weights, accelerated vaginal opening, and altered estrous cycles in young animals. …a reduction in litter size was evidence in genistein-treated animals. These compound-specific effects appeared to be enhanced in the offspring of prior exposed generations.

www.ncbi.nlm.nih.gov/pubmed/19159674

NIEHS Report; Deleterious effects on female reproductive system in adulthood.

www.ncbi.nlm.nih.gov/pubmed/17604387

Disruption of female reproductive system by soy phytoestrogen genistein in adulthood.

www.ncbi.nlm.nih.gov/pubmed/17250991

Infant girls fed soy show reestrogenization at 6 months…..Examination of infants consuming soy for plausible effects of estrogens is valid and repeatable

www.ncbi.nlm.nih.gov/pubmed /18335112

2006, Dietary component, such as fat or phytochemicals in plant foods, can have an opposite effect on breast cancer risk if exposed in utero through a pregnant mother or at puberty. Dietary exposure during pregnancy often has similar effects on breast cancer risk among mothers and their female offspring. There is extensive programming of the mammary gland during fetal life and subsequent reprogramming at puberty and pregnancy. Thus, dietary exposure during pregnancy and puberty may play an important role in determining later risk by inducing epigenetic changed that modify vulnerability to breast cancer. 

www.ncbi.nlm.nih.gov/pubmed/17261753

De-feminize female mice: 2010, Females exposed to (soy)daidzein showed significantly less ERalpha expression in bed nucleus of the stria terminalis and medial amygdale. Findings show that maternal exposure to daidzein has a masculinization effect on memory and social behavior, suggesting a potential role of ER alpha distribution in the brains…. 

www.ncbi.nlm.nih.gov/pubmed/20505512

2005, De-masculinize male mice: John Hopkins School of Medicine: Exposure to endocrine disrupting chemicals adversely affects reproductive development and behavior in males. Aggressive behaviors were decreased whereas defensive behaviors were increased in males that received the low-dose (soy) genistein diet. Exposure to genistein during critical periods of sex differentiation results in concurrent and persistent de-masculinization in male mice. Given the popularity of soy infant formulas the influence isoflavone exposure on reproductive and behavioral health in boys and men should be considered.  www.ncbi.nlm.nih.gov/pubmed/15708785